Great interest in the roles of Wnt signaling on bone mass followed the 2001/2002 discoveries that various LRP5 and SOST gene mutations in humans are responsible for dramatic alterations in patients with osteoporosis pseudoglioma, the HBM phenotype, sclerosteosis and van Buchem's disease.
Based on our experience in studies of hormone-therapy resistance in breast cancer, antiestrogen resistance is accompanied by dramatic alterations in the expression level of many genes, and alteration of DNA methylation may be one of the causes.
In this report, we elegantly demonstrated that UN-induced renal injury is associated with dramatic alterations in gene expression profile, as presented on the depicted drawing (figure 4).
Overall, the 2C results indicate that TCR cross-reactivity need not be driven by dramatic alterations in the TCR-binding site, the existence of different interatomic contacts within the interface notwithstanding.
It is conceivable that more dramatic alterations in the musculature were present in morphants with the bent phenotype.
As shown in Figure 7A, some of the NAMs we have identified here are likely to impose dramatic alterations in signaling networks, such as specificity switches that are analogous to introducing a new kinase and thus may play a driving role in oncogenesis.
Our observations provide new insights into the molecular pathology underpinning NF2 involving mutations in exons 2 and 3. Merlin, similar to ERM proteins, influences cytoskeleton dynamics, and when merlin is absent in SCs, dramatic alterations in the actin cytoskeleton are observed (Gonzalez-Agosti et al., 1996; Lallemand et al., 2009a).
For example, tumor cells are known to have dramatic alterations in the ability to uptake and metabolize nutrients, resulting in gross rewiring of the metabolic network.
Microtubule disruption has been shown to induce dramatic alterations in both the assembly and the spatial localization of SGs and PBs in different cell lines [29], [30], [31].
