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In PNPT1 knock-out mice, mitochondrial morphology and respiratory capacity are disrupted in a manner quite similar to the disruption in renal proximal tubular cells in patients with tenofovir-induced nephrotoxicity (Perazella, 2010; Wang et al., 2010).
When the normal correlations between the different modalities are disrupted in a systematic way it is possible to produce the types of illusions that are important in understanding how the brain represents the body, especially when this can be combined with brain imaging.
These oxygen gradients are disrupted in a range of diseases.
In the first step, samples are disrupted in a denaturing lysis buffer, and then subjected to acid-phenol/chloroform extraction.
The clustered alignment allows us to uncover sets of genes that are disrupted in a similar manner by the knockout, even when their expression profiles are quite different.
Knowing which genes are disrupted in a brain disorder such as autism will allow molecular diagnostic assays to be developed to better identify and define pathogenesis in affected individuals, and to do so at an earlier age.
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We investigated whether mitochondrial biogenesis and PGC gene expression are disrupted in an established model of Staphylococcus aureus sepsis both in mice with impaired innate immune function (TLR2−/− and TLR4−/−) and in wild-type controls.
The final pellet was resuspended in 0.5 ml isolation buffer and the cells were disrupted in a nitrogen cell disruption bomb (model 4639, Parr Instruments, IL) at 1200 psi for 10 min at 4°C.
Asteroid families are formed when an asteroid is disrupted in a catastrophic collision, the members of the family thus being pieces of the original asteroid.
Last but not least, a total of around 9% of parameters were disrupted in a meta-analysis (Table 2).
By definition, people with chronic diseases have ongoing medical needs that can easily be disrupted in a disaster situation.
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