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These are difficult to alter.
Maternal death is closely associated with socioeconomic deprivations, which are difficult to alter.
Although predisposing factors are present before ICU admission and are difficult to alter, precipitating factors occur during the course of critical illness.
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It's difficult to alter something that isn't known.
Entrenched buying patterns -- high-volume orders of white flour, for example -- can be difficult to alter.
It comes into operation without active control or attention by the individual, it is difficult to alter or suppress, and it is virtually unaffected by load.
John D. Morris, a retail analyst for Gerard Klauer Mattison, said that he feared retailers were overbuilding, but that it was difficult to alter construction plans at the drop of a market index.
The design of the wells meant that once they had been dug it was difficult to alter their level, so new wells would have been built as conditions changed.So what makes a "good" well?
Inflexible production processes, such as with mass production lines, where it is difficult to alter the design of a product or allow variation in the process sequences, means that the tech industry can be guilty of producing more equipment than the market actually wants or that doesn't fit exactly what the market needs.
For all the talk, however, it will be difficult to alter the government's role in housing finance, which has remained substantially unchanged for half a century — notwithstanding Fannie and Freddie's move from informal to formal wards of the state.
Standard immobilizations are not fully random processes, but the protein orientation may be difficult to alter.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com