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In summary, the careful selection of key components, identification of key characteristics and understanding of critical manufacturing steps are determinants of whether the nanoparticles will have the desired pharmacodynamics, PK, and safety profiles to achieve the intended therapeutic effects.
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Nevertheless, while objective evidence for effectiveness at community level is important, perceived effectiveness and feasibility are crucial determinants of whether existing evidence will be implemented.
This supports the view that a considerable element of chance has influenced the size of the gene families in Populus, and that stochastic events as well as subfunctionalization and neofunctionalization are important determinants of whether genes are lost or retained in a duplicated genome.
The most widely held criticism of this in vitro to– in vivo prediction approach is that genes or cells are not organisms and that the emergent properties of tissues and organisms are key determinants of whether a particular chemical will be toxic.
Barbara was a realist, and understood that the timing and machinations of politics and policy are key determinants of whether or not research findings are taken up.
As was the case for the sampling technique, general population distributions and uniformity of certain parameters within localities are important determinants of whether locally derived estimates can be applied nationally, and vice versa.
The vaccine coverage of pneumococcal types, vaccine percentage efficacy, and stage of HIV disease in vaccine recipients are critical determinants of whether this strategy will be of value in adults.
The length of time that a population has been displaced and the HIV prevalence levels in both area of origin and area of displacement are major determinants of whether the above factors lead to an increase or decrease in HIV infection rates [ 6].
A number of studies have observed that individual assessments of the benefits and risks of disclosure are important determinants of whether individuals disclose their HIV status to anyone, including sexual partners.
Spatial and temporal aspects of host and pathogen life-history characteristics are crucial determinants of whether or not hosts and pathogens interact, and if they do, the extent and nature of those interactions.
Furthermore, the presence or absence of the listed cardiovascular risk factors and comorbidities are not determinants of whether to provide acute reperfusion in the event of MI and thus do not act as confounders in the comparison.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com