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For example, if all cells are derived from initial progenitor cells, what directs differentiation towards glial cells versus adipocytes?
Importantly, it remains unclear whether the RANK-responsive TECs contained within the CD205− subset are derived from initial CD205+ progeny, or whether additional RANK+CD205− cells at early embryonic stages represent a separate stream of mTEC progenitors that do not pass through a CD205+ stage.
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Almost all data on drug-eluting stents (DES) fracture have been derived from initial platform of first-generation DES such as Cypher Bx® (CBX) and Taxus Express®.
These precede the asymmetrical ethylene production and differential stem growth, which was derived from initial shrinkage of the upper stem side and a subsequent elongation of the lower stem side.
Using this strategy, MAT a strain YO528 was derived from initial isolate EC-33.
The apparent steady-state parameters for APAD+ were derived from initial velocity versus dinucleotide concentration at saturating IMP (500 μM) using eq 1. Ligand was successively added to 0.1−0.15 μM CpIMPDH in assay buffer at 25 °C.
Rather than imposing a set of conditions, the nature of the conditions included in the CCT arm were derived from initial consultations with a group of community members and other stakeholders.
Early models of the NPC gating mechanism were derived from initial EM studies, which linked the biophysical origin of the selective gate to the presence of a "central plug" or "central transporter" module located within the NPC (Akey 1989, 1990).
Importantly, although the gene signature for the AC1 and AC2 subgroups was derived from initial analysis of a small cohort comprising only nine never-smokers, it was successfully validated across much larger AC data sets, e.g., the DCC (n = 349), profiled by different microarray platforms and comprising in total 687 AC tumor cases.
Second, as some of the parameters for the CG-BD runs are derived from the initial structure, alternative starting conformations reduce undue dependence on the initial conditions.
When, however, data are collected on segregating populations for a few generations apparent single gene effects may be due to the effects of closely linked loci, especially when these populations are derived from an initial cross of parental strains which differ widely in the character in question.
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