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The input data for the available gene prioritization methods are derived from functional annotation, protein protein interaction (PPI) data, biological pathways and literature.
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Therefore, phenotypes of AGRPPdk1−/− mice were derived from functional defects, but not loss of AGRP neurons.
This might be derived from functional redundancy among the Ena/VASP family proteins because the expression of the Ena/VASP family of proteins varies in different types of cells and tissues [38], [39], [40].
Language lateralization indices were derived from functional magnetic resonance imaging.
A total of 4,984 ORFs were identified with conserved domains (Additional file 3), suggesting that such ORF-harboring contigs were derived from functional protein-coding genes as well.
Insights into the regulatory components of xylem development, including transcriptional regulators, have been derived from functional analyses in the herbaceous model plants Arabidopsis thaliana (L).
First, because ammonia transport across the blood-brain barrier is both carrier mediated and pH dependent, data are required on the acid-base equilibrium that could be derived from (functional) proton nuclear magnetic resonance measurements.
Further evidence that our newly identified coding variants do not cause disease was derived from functional analyses: none of the variants leading to amino acid changes in the respective ACT1 proteins affected TRAF6 interaction.
Pseudogenes have been regarded as being derived from functional-encoding genomic DNA sequences that have accumulated disabling mutations (frameshifts and premature stop codons) that make them non-coding protein genes.
Despite these differences in mechanism, comparable energy barriers (differing by ca. 2 kcal/mol), are derived from density functional theory (DFT) simulations.
The networks presented are derived from a functional analysis of gene sets previously identified from microarray studies (Table 1).
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