In 2001, it was discovered that apoptotic blebbing is dependent upon activity of the actomyosin regulator ROCK1 kinase.
In the presence of Hedgehog pathway activation Hes1 activity is high but this activity is largely lost in the absence of Rbpj, suggesting that most of the Hedgehog-dependent Hes1 activity is dependent upon active canonical signaling.
Some phosphorylated forms of Shs1 that are dependent upon CDK activity are present throughout the cell cycle, but Pcl1, Pcl2, Cln1, and Cln2 are only present during G1.
Thus, in L and BP cells, the levels of c-Myc, XIAP, VEGF and Hif-1α proteins are dependent upon AMPK activity, implying that AMPK might be involved directly in the regulation of IRES-dependent translation.
All these phenotypes are dependent upon the catalytic activity of the W438 hPolλ.
The phosphorylation levels of Rb/p105 are dependent upon the CDK activity present in the cell.
The functions of the PRL/CypB complex are dependent upon the PPI activity of CypB.
Not surprisingly, many cancer cells are dependent upon the transport activity of system xc− for growth and survival.
It has been generally assumed that the antiproliferative effects of NASIDs are dependent upon inhibition of COX activity and prostaglandin synthesis.
Following pathway activation, we perform gene expression analysis to capture the acute transcriptional events that are dependent upon that pathway's activity.
Aromatic amino acid hydroxylases are dependent upon the cofactor tetrahydrobiopterin for activity.
