These results suggest that a large fraction of the low frequency nonsynonymous SNPs are deleterious.
In the absence of Mad2p-dependent spindle checkpoint, both mutations are deleterious.
Frequently, however, radical alterations to a gene's dosage are deleterious.
However, they clearly demonstrate that not all perturbations of ETC function in mammals are deleterious.
Mutation and recombination probabilities are uniform across the genome, and all mutations are deleterious.
We have identified polymorphic structural variants in a natural population and found evidence that many of these variants are deleterious.
The hypothesis that we want to test is that SNVs that cause changes in the structure/disorder tendency are deleterious.
Gene regulation is thought to be in a well-balanced state, and any mutations that disturb the balance are deleterious.
We suppose that s > c, so that non-duplicated genes are beneficial, but duplicate copies are deleterious.
Ordinarily K a / K s values much less than one are observed, indicating that most amino acid mutations are deleterious.
They go round and slaughter insects that are deleterious in the garden like caterpillars and flies.
