Secondly, the definition of the starting time for the duration until AT is defined significantly different across the available studies and includes hospital [ 33, 35] or ICU admission [ 2], onset of arterial hypotension [ 3, 34], and the time when cultures were obtained [ 17, 36].
Using this confidence interval, 1% of genes with the greatest-fold change or least-fold change are defined as significantly up- or down-regulated (see Materials and Methods).
Pathways with corrected p-value less than 0.05 are defined as significantly enriched terms.
GO terms fulfilling this condition are defined as significantly enriched GO terms in DEUs.
GO terms with corrected p-value ≤ 0.05 are defined as significantly enriched in target gene candidates.
GO terms with corrected p-values of ≤ 0.05 are defined as significantly enriched in target candidate genes.
Vulnerability genes are defined as genes showing significantly higher expression in CA1 than CA3 (FC >1.2) and increasing with AD to a significantly greater degree in CA1 compared with CA3 (FC in CA1 >1.2 and FC in CA1 > FC in CA3).
The calculating formula is the same as that in GO analysis, the pathways with a Q value of ≤ 0.05 are defined as those with significantly differentially expressed (enriched) genes [ 64].
Optimal codons are defined as those that occur significantly more often in highly expressed genes relative to their frequency in lower expressed genes.
The Z statistic tests whether W is significantly different from 0. A Z < –1.96 is defined as significantly lower and Z > 1.96 as significantly higher observed mortality than expected.
Superiority was defined as significantly reduced pain score with total hip arthroplasty (p < 0.05) and significantly improved functional score (SF-12 version 2, 6 points).
