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We recently showed that many Somalis, especially former Somali liberation fighters, who had fought against the Siad Barre regime, are currently functionally impaired by psychiatric disorders [ 1].
We use standardized nomenclature following the Human Genome Organization Gene Nomenclature guidelines and are currently functionally annotating chicken, cow and sheep gene products using the Gene Ontology (GO).
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However, these are currently structurally and functionally of limited complexity and necessitate self-organization and recapitulation of tissue development mechanisms in vitro.
In contrast, complementary experimental efforts are currently lacking to functionally annotate the many recently sequenced mammalian genomes.
Even though no such products are currently known from functionally characterized PKS-PKS hydrids [ 38], it is reasonable to consider that pneumocandins might be encoded by one of the PKS-NRPS hybrid proteins.
An alternative for taking biopsies could be molecular imaging methods like positron emission tomography (PET) and single photon emission computed tomography (SPECT) that are currently being developed to functionally assess immunophenotype of breast cancer metastases [ 24- 26].
In Arabidopsis (TAIR: http://www.arabidopsis.org) there are currently 3 annotated but functionally unconfirmed ACs (At1g26190, At1g73980 and At2g11890) and they all do contain the motif [RKS]X[DE]X 9,11)[KR]X(1,3)[DE].
Accordingly, functionally selective ligands are currently pursued as next-generation drugs for superior treatment of heart failure.
These and other functionally related genes are currently under intense scrutiny for common low-penetrance cancer-predisposing alleles.
Overall, 21% of bird species are currently extinction-prone and 6.5% are functionally extinct, contributing negligibly to ecosystem processes.
While many of the phenotypic differences between human and chimpanzee may result from changes in gene regulation, only a handful of functionally important regulatory differences are currently known.
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