Sentence examples for are critical for developmental from inspiring English sources
Core PcG genes modify chromatin structure to prevent transcriptional activation of key target genes, including the well-characterized homeotic genes that are critical for developmental patterning and cell fate determination [30].
However, it is clear that contact inhibition is critical for developmental organization of multicellular organisms and for reorganization of tissue after injury [19].
The CXCL12/CXCR4 axis is critical for developmental processes including lymphopoiesis, and central nervous system and cardiac development, and knockout of either the ligand or receptor in mice results in embryonic lethality [7].
In line with our findings, studies in Drosophila, zebrafish and mouse have defined a Notch-Runx1 pathway to be critical for developmental specification of hematopoietic stem cell fate and homeostasis of hematopoietic stem cell number [28] [30].
DOI: http://dx.doi.org/10.7554/eLife.00290.017 Since the ratio of kif2a to importin α was critical for developmental spindle scaling, we investigated in more detail the mechanisms regulating importin α levels.
In addition to plant sensing of harpins, the subsequently activated physiological and pathological responses are critical for the developmental and immune roles that harpins play in a variety of plants (Li et al. 2015; Tian et al. 2016).
Given that most of the aforementioned signaling pathways are critical for certain developmental processes and patterning events, one might have predicted from the in vitro studies that secreted sulfatase-deficient mice would have exhibited profound developmental defects in a multitude of organ systems.
Our results indicate that both the timing of exposure and the dose level are critical for the developmental toxicity of CPF.
SEPALLATA (SEP) genes form a subfamily of MADS-box transcription factors that are critical for a number of developmental processes.
MicroRNAs are critical for the regulation of multiple developmental, stress related and other physiological processes in plants.
The identification of specific chromatin-associated proteins as marks of enhancer activity has been another effective approach in the identification of sequences that are critical for site- and stage-specific developmental expression of individual genes (36).
