We extended this analysis of ChIP-Seq data to 41 E-boxes in 15 'reference clock genes' that are thought to be core regulators of the circadian clock (Rey et al., 2011).
CDKs (cdc2) and cyclins are core regulators in the cell cycle, and the activity of CDK/cyclin complexes is controlled by several regulators [ 6, 45, 49].
The role of these proteins in axonal and synaptic pathology remains unclear, although previous studies have suggested that Pttg1 may modify ubiquitination pathways in synapses and axons (29, 31) and VDAC1 is known to be a core regulator of mitochondrial form and function (30).
Those results clearly show that miR-200a is a core regulator of module 25, most probably with other members of the miR-200 family.
Notably, S6K is the core regulator of glycolysis [ 17].
Moreover, SNAI2 is a core regulator of EMT, a key process in cancer pathogenesis and tumour progression by which epithelial cells acquire a mesenchymal phenotype with invasive and migratory properties.
As a proof of concept, Traeger and collaborators found that the fruiting body specific transcription factor pro44 (orthologous to the velvet regulon-associated transcription factor nsdD) in the ascomycetes Sordaria macrospora and Pyronema confluens is a core regulator of perithecia maturation.
The second regulator in the list is one of the core regulators of the cell cycle, E2F2 (Trimarchi and Lees, 2002).
In general, histone demethylases are tightly integrated in the transcriptional factor regulatory networks in ES cells., To give one example, the high-ranking gene JARID2 is the target for seven core regulators of ES cells.
The nutrient sensor mTOR (mammalian target of rapamycin) is likely the core regulator of autophagy.
