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To examine proteasome inhibition in living cells, we used stably transfected HEK293 cells (HEK293PS) that are continuously expressing the ZsProSensor-1 protein, a proteasome-sensitive fluorescent reporter.
To examine whether tyropeptin-boronic acid derivatives inhibit the proteasome in tumors, we used HEK293PS cells that are continuously expressing a proteasome-sensitive fluorescent protein.
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HPV oncoproteins E6 and E7 are continuously expressed and are essential for maintaining the growth of HPV-associated tumor cells.
Although CDKs are continuously expressed, the concentration of cyclins are regulated by the cell cycle-dependent synthesis and ubiquitin-mediated degradation during the cell cycle[3] [5].
The majority of macronuclear nanochromosomes are continuously expressed during vegetative growth of the cell.
Viral E6 and E7 genes are continuously expressed and are largely responsible for the oncogenic activity of these viruses.
In host cells possessing the P1 genome, stable Doc toxin and unstable Phd antitoxin are continuously expressed [ 6].
Pathological vascular calcifications may arise due to loss of mineralization inhibitors, which are continuously expressed in healthy vascular tissue [ 15].
(C ) Venn diagram showing that most genes, 85%, are continuously expressed as they are detectable at each time point of oogenesis (3Pseq: red; RNAseq: green).
In frog (Xenopus laevis), an increasing number of miRNAs are expressed at specific stages as embryonic development proceeds, and are continuously expressed until the tadpole stage [ 49].
Genes that are continuously expressed in the mantle – Has-ferrt, Has-ubfm and Has-calmbp1 – are likely to play fundamental roles in biomineralisation.
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