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Stratigraphic, geochronologic, and available paleomagnetic data are consistent with linkage of western Laurentia to Australia East Antarctica within Rodinia, followed by protracted rifting and drift during Cambrian time.
Although the expected number of integration events is an approximation based on size and not the distribution of TA dinucleotides on each chromosome, the data are consistent with linkage of the Tg(T2/OncZ, ß-actin:RFP is6 concatemer to chromosome 16.
Our data are consistent with linkage maps and knowledge of sterility between H. melpomene and H. cydno.
Our results are consistent with linkage studies in RA that have not found a genetic contribution for the region at 2q24.3 that encodes IFIH1 [ 18].
Phenotypic characterization of teeth and visual function in the published and new families reveals a consistent syndrome in all seven families, and all link or are consistent with linkage to 2q11, confirming the existence of a genetically homogenous condition that we now propose to call Jalili syndrome.
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Initial microsatellite genotyping using selected markers from the published linkage interval[22] on chromosome 1 were consistent with linkage in family F105 and F115 (see Materials and Methods and Fig. 2 for ascertainment and descriptions of families segregating SCCD).
Analysis of polymorphic markers provided evidence against linkage to BRCA1, but the sibship was consistent with linkage to BRCA2.
Cosegregation of the c.14130-2A>G and p.Ser3074Phe RYR1 variants in family 2 is consistent with linkage (maximal LOD score 1.9, the threshold for suggestive linkage).
The subsequent description of an affected sib pair from Kosovo that had a similar clinical phenotype and that was consistent with linkage to 2q11 suggested that the combination of CRD and AI might exist as a genetically homogenous syndrome.
Furthermore, the observations of increased oxidative damage and reduced repair in Alzheimer's disease are consistent with the linkage of defective repair of oxidative genome damage with neurodegeneration33.
The binding behaviors of these fusion proteins and the native protein subunits are consistent with cooperative linkage between protein-association and DNA-binding equilibria.
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