This finding along with loss of heterozygosity of the neurofibromin 1 locus, as recently reported by SNP genotyping analysis on the pooled samples from the same 10 neurofibromas and 10 MPNST (Feber et al, 2011), is consistent with functionally biallelic inactivation of neurofibromin 1 in these tumours (Legius et al, 1993; Colman et al, 1995).
These and other results are consistent with MED28 functionally linking membrane receptor signaling to cytoskeletal changes.
Taken together, these results are consistent with a functionally distinct role for PIPKIγ_i5 in cadherin biology.
Both subjects reported having no sleep disorders and normal age-appropriate 24-hr sleep/wake patterns, as confirmed by quantitative assessments of circadian rest-activity behavior carried out with wrist actigraphy while they lived at home [14, 15]; these results are consistent with a functionally intact retinohypothalmic tract [1, 16].
This result is consistent with functional studies, suggesting that the N-terminal region of hMC4R is functionally important (5, 42).
These data are consistent with VPS5 orthologues being functionally distinct from VPS17 orthologues in their ability to remodel liposomes into tubules.
These data are consistent with the existence of functionally selective ganglia that have been demonstrated in other species (Ardell and Randall, 1986; Gatti et al., 1995, 1997; Randall et al., 1986a, 1986b).
Thus, the disparities between VEGF-A concentrations and angiogenic activities are consistent with the presence of both functionally active and inactive form of VEGF-A unbound and bound with soluble GAGs, respectively.
These observations are consistent with the mutated residues contributing to functionally important yPrp3-yU4/U6 interactions, as seen in our binding assays and yPrp3CTF -yU4/U6stem II+10nt crystal structure.
These results suggest that the cell types targeted in vivo by VRP carrying mutant or wild type glycoprotein spikes are functionally different, and are consistent with previous findings suggesting that wild-type VEE glycoproteins preferentially target professional antigen presenting cells that use peptides generated from the degraded antigen for direct presentation on MHC.
