The 5' flanking region of the gene is conserved across Drosophila species, with the proximal 300 bp being conserved out to D. virilis and a further 600 bp region being conserved amongst the melanogaster subgroup (D. melanogaster, D. simulans, D. sechellia, D. yakuba, and D. erecta).
Many sleep genes, she points out, are conserved across species.
These coded for a series of proteins which, as it turns out, are conserved across other species of fungal rusts.
Thus, the genome of D. geothermalis is a resource of major importance in delineating a reliable minimal set of resistance determinants, by corroborating those that are conserved and ruling out those which are unique.
In addition, these three proteins have almost the same 14 key residues for PPIase activity and are conserved in 12 out of 14 key residues of hFKBP12 for PPIase activity, suggesting that they are catalytically active isoforms (Table 1).
Of polar residues that are conserved and buried and carrying out this role, cysteine, glutamine, threonine, asparagine and serine have the highest propensity to form such interactions (Table 2 and see Additional file 3, Figure S2C - grey bars).
These roles are conserved in Physcomitrella and are carried out by PpCCD7 and PpCCD8.
Comparison of the sequences of DGC protein revealed that three cysteines are conserved in MSDGC-1 out of seven in MtbDGC.
At this point we were left with a total of 72 candidates that are conserved in 4/6 genomes, out of which 29 are conserved in 6/6 genomes.
Similarly, almost all putative partial CUT loci are present in both Xcv and Xac, but only 9 out of 15 are conserved in Xoo strains.
