Generally, it is quite complex to generate the likelihood confidence region since many function evaluations have to be performed in the surrounding of the parameter estimates θ ^.
For some interleaving functions it is too complex to generate a full vector of addresses every clock cycle.
Finally, information about the 'upstream' modulators of gene activity, such as the methylation of specific CpG groups, histone modifications and changes in chromatin conformation, is much more complex to generate and analyze than raw genome sequence data.
A microRNA is transcribed as a long, primary miRNA (primiRNA) which is cleaved by the microprocessor complex to generate a miRNA precursor (premiRNA) that is exported to the cytoplasm [ 75].
After transcription, primary miRNAs (pri-miRNAs) are cleaved by the microprocessor complex to generate precursors sequences with hairpin structure.
The resulting proton gradient across the thylakoid membrane is used by the ATP synthase complex to generate ATP in the chloroplast stroma, where the light-independent carbon fixation reactions occur.
BOND mutual funds have not always been investor favorites, perhaps because they are complex and tend to generate modest if steady returns.
A further complication is the propensity of ubiquitination complexes to generate chains of varying lengths at a given modification site in vivo, making detection of ubiquitination by traditional size separation techniques challenging.
Taken together, it appears that at least three distinct stem cell coactivators (one being the XPC complex) are required to generate a full, OCT4/SOX2-dependent transcriptional response.
The study of PANK2 function is complex, and efforts to generate animal models of disease by knocking out the gene in flies and mice have generated incomplete phenotypes, lacking signs of neurodegeneration and/or of brain iron accumulation (5, 6).
