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Analysis of public datasets using cBioPortal22,23 revealed that L-type calcium channels are commonly altered in patient samples of different cancer types (Supplementary Fig. 4A).
Angiogenesis-related molecular markers are commonly altered in urothelial carcinoma of the bladder, making them a target for therapy.
Moreover, these genes specifically implicated in HER2 oncogene-driven transformation are commonly altered in human breast cancer cells.
Chromosomal structural abnormalities leading to copy number changes, including deletions and amplifications, are common in cancer and certain regions are commonly altered, suggesting their role in the pathogenesis of this disease [1], [2].
This meta-analysis defines a signature profile of normal, quiescent stem cells present in the BM of mice and reveals novel molecular pathways that are commonly altered when HSC are uprooted from their normal quiescent niche.
These functions and molecules are commonly altered in human cancers.
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We also found a substantially elevated frequency of TP53 mutations in the subset of BRCA1 methylated tumours, which has not been reported previously, suggesting that BRCA1 methylation might lead to alterations in the same molecular pathways as those known to be commonly altered in familial BRCA1 tumours.
Sleep is commonly altered in critically ill patients.
The p53 tumor suppressor gene is commonly altered in human tumors, predominantly through missense mutations that result in accumulation of mutant p53 protein.
Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, is commonly altered in different tumor types, leading to abnormally regulated kinase activity and excessive activation of downstream signaling cascades, including cell proliferation, differentiation, and migration.
Ash is commonly altered on and/or in the seafloor by diagenesis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com