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Both products are classically thought to express predominantly in oligodendrocytes.
PER and CRY proteins are classically thought to translocate into the nucleus to inhibit CLOCK∶BMAL1 mediated transcription, thereby closing the negative feedback loop [1].
Since functional Gβγ subunits in neurons are classically thought to associate with Gαi/o, we first utilized pertussis toxin (PTX) to specifically inhibit these Gα subunits.
These cells are classically thought to derive from post-embryonic lung fibroblasts.
Lysosomes are classically thought to be vesicular organelles, where they serve as depots for cargo delivered via endosomes or autophagosomes.
Paradoxically, some GDIs and GAPs, which are classically thought to be negative regulators of the GTPases, have oncogenic functions [ 7, 8].
Similar(45)
Seizures in infancy were classically thought to cause brain lesions that led to epilepsy in adulthood.
Metabolic acidosis is classically thought to induce an enhanced ventilatory pattern, irrespective of the underlying aetiology.
ICP0 is classically thought to perform the majority of its functions early in infection while localized in the nucleus [15], [16], [17].
The finding that the effects of EE on visual system development are present in the retina is particularly relevant, since this structure has been classically thought to be resistant to experience-dependent alterations.
Although these mutations were classically thought to be comprised of a few genes (e.g. Apc, Kras, Trp53), recent large-scale sequencing efforts revealed that any given tumor includes (on average) 80 mutations, with as many as 15 lying in frequently mutated "driver" genes [2].
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CEO of Professional Science Editing for Scientists @ prosciediting.com