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Estrogen receptors are classically known as ligand-activated transcription factors that regulate gene transcription in cells in response to hormone binding.
MDSCs are classically known to decrease CTL response, mostly through destabilization of T-cell receptors and decreased expression of certain CD3 subtypes, ultimately leading to CTL apoptosis.
Both parameters are classically known to be dependent on presynaptic mechanisms, directly suggesting the presence of presynaptic ASIC1a channels.
Although caspases are classically known for their role in apoptosis, their involvement in biological processes apart from cell death has recently received increased attention.
(12, 23 ) RAB proteins are classically known to participate in the endocytic pathway and their role in exosome release is no surprise.
Macrophages are classically known for their pro-inflammatory roles in innate immunity and more recently for their active contribution to the resolution of inflammation and tissue repair [ 1- 6].
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The space L2hol is classically known as the Segal Bargmann space.
Stroganoff is classically known as a beef dish, but we decided to replace the beef and use seitan instead.
Seems we discovered something, here: vodka is classically known as a very chameleonic drink, a neutral-leaning spirit that can take on any flavor, meld with it, make it its own.
At the neuronal level, repeated or prolonged exposure to a stimulus (adaptation) is classically known to reduce the neurons' responsiveness to the same stimulus.
In response to growth factors, hormones and amino acids, mTORC1 is classically known to regulate cell growth and proliferation through modulation of protein synthesis by phosphorylation toward its downstream effectors, S6K1 [8] and 4E-BP1 [1].
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CEO of Professional Science Editing for Scientists @ prosciediting.com