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Our estimates of the annual number of avoidable cancer deaths are certainly large, whether assessed against the mean or the highest European survival, but they are well below the previous estimates (10 000 and 25 000 deaths a year, respectively), which were acknowledged as crude (Sikora, 1999), and are clearly not plausible.

While some aspects of a performance — like balance and projection — are certainly difficult to assess on a computer and an ordinary sound system, this one proved a rewarding interpretation.

Altogether, although this is a proof of principle study and further studies are certainly needed to assess the potential of this approach in the clinic, multispectral optical imaging could possibly improve the current management of patients from early diagnosis of cancer to surgical procedures, treatment decision-making and monitoring of treatment response.

The data are certainly adequate for assessing the size of the colony until 1970, and for indicating the approximate timing and rate of subsequent decline.

These laboratory studies are certainly useful in assessing the learning abilities of animals, disentangling genetic from environmental effects, controlling for confounding factors and testing predictions made from theoretical models (e.g. producer-scrounger models, reviewed in [13]).

Taken with our data showing strong cooperativity between these agents in rejecting B16-BL6 melanoma, further studies are certainly warranted to assess the safety of using 4-1BB antibodyandibody and CTLA-4 blockade in combination.

To this end, additional, larger, and controlled studies are certainly needed to assess the impact of low-flow CO2 removal on ventilator settings and patient prognosis.

IMT may help difficult to wean patients to 'work it harder', but further studies are certainly needed to assess if it may work to 'do it [the weaning process] faster'.

Despite these limitations, the data obtained are certainly useful in preliminarily assessing safety and planning future studies.

On January 10th a particularly idiotic individual from the Shiv Sena, a Hindu nationalist political party and an ally of the opposition Bharatiya Janata Party, reportedly even called for India to "nuke" Pakistan in revenge for the border incident.Another detail is certainly worth assessing.

Self-report methods such as questionnaires are certainly not ideal tools for assessing subjective experience.

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