Sentence examples for are broadly implicated in from inspiring English sources

Finally, integrins are broadly implicated in bone metastasis due to their ability to induce mitogenic intracellular signaling.

These small interfering RNAs are broadly implicated in viral infection of mammalian cells, with either positive or negative effects on viruses' replication.

Th17 cells, a recently discovered subset of T helper cells with a highly inflammatory nature, can secrete several potent proinflammatory cytokines, including IL-17A and IL-17 F, and are broadly implicated in inflammatory and autoimmune diseases [ 7- 9].

The results of an analysis of variance showed that, compared with the control group, ADT patients had at 6 months a decrease in MPFC connectivity (p < 0.001, uncorrected; Figure 3) with the dorsolateral prefrontal cortex (DLFPC), right insula, right superior temporal gyrus, and the rostral anterior cingulate cortex, structures that are broadly implicated in cognitive control.

Natural antisense transcripts (NATs) have been broadly implicated in regulating gene expression and chromosome structure [29] [34].

Decreased expression of Ppara has also been observed in aging heart, liver, and kidney [72] and recently it has been broadly implicated in aging and systemic inflammation [73].

In addition to effects on eicosanoid metabolism TGM2 also activates the transcription factor NFκB that is broadly implicated in the generation of pro-inflammatory cytokines in asthma and other inflammatory diseases, and induces iNOS via NFκB [42].

Additionally, GH has been broadly implicated in aging and neurogenesis, as neural precursor cells in the subventricular zone proliferate in response to central GH infusion [ 12].

In summary, disruption of the homeostatic balance between proliferation and apoptosis has been broadly implicated in cancer and silibinin tips the balance away from development of colorectal cancer.

Although published data implicates non-canonical Wnt signalling as a positive regulator of cell migration [ 30, 32, 33], DLG1 has been broadly implicated in maintaining integrity of the epithelium, aberrations of which are responsible for certain human diseases [ 34, 35].

The paralog PIK3C-γ or PIK3CG is broadly implicated in many diseases due to its role as a downstream signaling component of chemokine receptors that modulate inflammatory pathways [ 12].