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"[T]he reliability concerns currently being raised … presume inflexible implementation, are based on worst-case scenarios, and assume that policy makers, regulators and market participants will stand on the sidelines until it is too late to act".
Dose modifications during a cycle were based on worst toxicity attributable to the study drug observed during that given cycle.
IN THE COMMENTS to my post on climate change, rc says:Try that out on the American Enterprise Institute, which issued this release yesterday: The just-released Stern Review on the Economics of Climate Change, which was commissioned by the British government, is based on worst-case climate scenarios.
The method proposed here, named (Mu-μ -iteration, is based on worst-case analysis and Mu-μ -iterationenstructure assignMu-μ -iteration
Initial conceptual design efforts were based on worst-case combinations of possible currents that the power supplies could deliver.
Earlier on Tuesday, Zinke also claimed that these findings were based on worst-case scenarios.
We also propose a set of PUF metrics that are based on the Worst Case (WC) PUF performance.
An important factor leading to better performance for the measurement results is that the analytical models are based on the worst-case situations, in which the consideration of excess requests within each average cycle of user requests by N Users does not take into account the possibility that some of the requests generated in the practical scenarios would be accessing data already in the cache.
The quantities of water maintained and apportioned are based on the estimated worst possible sequence of flood and drought events over a period of 100 years; and generally, one-fourth of the total capacity of Lake Nasser is reserved as relief storage for the highest anticipated flood during such a period (called "century storage").
*Maximum and minimum scores are based on best and worst responses to all items on the SF-36 and SF-12.
The static and dynamic schemes are based on the analysis of applications' worst case execution time (WCET).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com