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It is also known that aortic atheroma (AA), especially those ≥5 mm thick and/or protruding and/or mobile are associated with stroke.
To address this, we have cited previous meta-analyses which show substantial evidence that these variants are associated with stroke.
Male gender, older age, hypertension, hyperlipidemia, diabetes, traumatic brain injury, malignant brain tumors, mental disorders, Parkinson's disease, and Alzheimer's disease are associated with stroke [ 1, 2, 11, 12, 19, 20].
There is wide variability in both stroke and bleeding risk, and, because different comorbidities are associated with stroke and bleeding, the benefit-to-harm ratio can reverse depending upon the particular combination of comorbid conditions [ 6].
In conjunction with Table 4, one can infer that IGFBP4 and IGFBP2 are associated with stroke risk beyond that attributable to the established biomarkers considered here, while there is little evidence for further association with IGFBP6.
SigCS base will allow researchers in molecular biology and genetics who study the causes and mechanisms of cerebral stroke to efficiently evaluate thousands of genomic variants and genes that are associated with stroke and its etiologies, as well as relevant annotated data from public molecular biology databases.
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Hypertension (HR 2.81; 95% CI 1.49 to 5.30) and diabetes (HR 2.23; 95% CI 1.12 to 4.44) were associated with stroke; associations were statistically significant for hypertension in 'high prevalence' countries and for diabetes in 'low prevalence' countries (Table 4).
49 Interestingly, all three gaseous pollutants derived from combustion (nitrogen dioxide, sulphur dioxide, and carbon monoxide) were associated with stroke, and this was consistent with reported associations with admission for heart failure and acute myocardial infarction.
Headache such as migraine is associated with stroke.
It is also possible that the benign course of our RCVS patients were related to the absence of postpartum state and cannabis use, as both have been associated with stroke and poorer outcome [20, 21].
In conclusion, larger LAA volume is associated with stroke in the setting of AF, and this measure can potentially improve risk stratification for stroke risk management in AF patients.
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