However, they have been criticized for being applied in isolation and not easy to integrate.
A major conclusion is that classical optimization techniques cannot be applied in isolation to derive effective solutions, but rather as a means to fine-tune an already developed solution that nearly satisfies the criteria.
While prospect theory is useful in understanding how young adults make decisions concerning health insurance, we argue that this conceptual framework should not be applied in isolation.
This APACHE-based model showed improved discriminatory power in comparison to the EMShockNet model (AUC 0.79 when AP3no-ox was applied in isolation versus AUC 0.81 when AP3no-ox was applied in combination with other variables listed in Table 6).
If NIBS is applied in isolation (i.e., at rest), the functional state of the stimulated brain networks is ill defined and may spontaneously fluctuate rendering NIBS less efficient.
For example, a global change experiment in a Californian grassland found a CO2 stimulation of plant growth when CO2 was applied in isolation but not in combination with warming or N addition (Shaw et al. 2002; Dukes et al. 2005), and similarly, CO2 effects on N2O emissions were dampened with other factors (Brown et al. 2012).
This method could be applied in isolation to identify potential targets for drug discovery or, as is the case here, used as a preliminary screen to reduce dramatically the workload required for a PCR footprinting and sequencing follow-on strategy to locate unambiguously transposon inserts, and hence infer the essential genes.
The 1ED020I12-F driver ICs are applied in the driver circuits to realize isolation and amplification.
Lectin affinity chromatography, such as immobilized Concanavalin A, was applied in the isolation of glycopeptides that express biantennary and hybrid N-linked structures and high-mannose glycans, which are abundant in both embryonic stem cells and embroid bodies stages (Alvarez-Manilla et al. 2010).
Wigglesworth et al. [ 10] concluded that either isolation capacity needs to be increased or evidence-based risk assessment shall be applied in situations where isolation demands exceed availability.
