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The phrase "are always substantial" is correct and usable in written English.
It can be used to describe something that consistently has a significant amount or importance.
Example: "The contributions of volunteers are always substantial in community projects, making a real difference."
Alternatives: "are consistently significant" or "are invariably considerable".
Exact(2)
Those opportunity costs are less immediately visible and can be measured in many different ways, but they are always substantial.
In the publication of Draisma et al (2003), the 95% confidence interval for proportion of overdetection was 46 57%, which means that despite the uncertainty, the costs for overdetection are always substantial.
Similar(58)
"There was always substantial confusion among roommates as to who called whom, and who had or had not paid the phone bill," Tom remembers.
At first you just see movement, much of which is neither pretty nor obviously expressive, but it's always substantial, complex, arresting.
Nearly all of the stabbers were killed or wounded by Israeli security forces, whose presence on Israeli streets, particularly in Jerusalem and the West Bank, is always substantial.
They're always substantial films produced with loving care and extras that set the industry standard.
Although this is not the first seal of a woman to be found, such seals are always of substantial importance because they were, and thus are, quite rare.
You are absolutely right that the operations and support costs are always a substantial part of a weapon system's true costs, and that, at least here on Earth, we have traditionally had a hard time predicting those costs.
It is going to be substantial sums but when you have got the Queen and other world leaders coming in for this funeral, then you are always going to have substantial security costs.
Corresponding to Figure 20A, the cables are not stretched to be horizontal, but rather they are always hung so as to have substantial curvature.
Some of the differences are minor, but it is apparent that where there are substantial differences, they are always in one direction, with our systematic and arguably more complete analysis providing lower smoking-adjusted RRs than theirs.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com