However, the clinical translation of this concept is hampered when repeated doses of medication must be administrated over an extended period of time.
Copper chelating agents are widely used to restore hepatic copper homeostasis, but they must be administrated over a lifetime and have little effect in severe cases.
Because the highest dose (3 × 5 mg) is administrated over several days, this results in a total of 7 days after the first 5-mg injection, and thus the effect is similar to the result observed with the 5-mg dose.
Thirty million doses of this vaccine, combined as DTP, are administrated to Brazilian children every year, free of charge, with over 95% of coverage, without major adverse events.
Etanercept and adalimumab are administrated subcutaneously (SC).
Death notification forms are administrated by DHA.
Eribulin mesylate was administrated intravenously over 2 to 5 minutes on days 1 and 8 of a 21-day chemotherapy cycle, according to the product guidelines.
Plasma exchange and glucocorticoids were administrated in over 80%% of cases with 65.7%% remission rate, while additional cytotoxics or rituximab was mostly used in refractory sTTP and achieved over 90%% of remission rate.
Parenteral nutrition was administrated continuously over 24 hours, starting on the day after admission when the patient was hemodynamically stable, or if not, as soon as possible (Day 1 is defined as when parenteral nutrition was started).
The simplified FOLFOX-4 (Oxaliplatine, ELOXATINER (85 mg/m), with simplified LV5FU2) is administrated intravenously over 48 hours once every two weeks (i.e. on d1/d2, d15/d16, d29/d30 etc).
