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Preclinical and clinical data on their safety when they are administered alone are available.
These antigens are administered alone or after being pulsed to, or incubated with, antigen‐presenting cells (dendritic cells or other cells).
So far, no systemic changes in the pharmacokinetics of irinotecan and its metabolites have been described from cycles 1 to 2 when the agents are administered alone.
Furthermore, through its action on nuclear factor-κB levels, APC also reduces the level of tumor necrosis factor, an effect not seen when iNOS inhibitors are administered alone [ 69].
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Mitochondrial respiration was measured in real time, while specific inhibitors of the major oxidative pathways were administered alone and in combination.
Manganese was administered alone at 15 mg/kg body weight or orally co-treated with quercetin at 10 and 20 mg/kg body weight for 45 consecutive days.
Melatonin (10 mg/kg) or NAC (150 mg/kg) were administered alone or in combination, intraperitoneally, 15 minutes prior to ischemia and just before reperfusion.
MSCs can be administered alone via percutaneous injection or implanted during open surgery with a biomaterial, usually biphasic hydroxyapatite/β-calcium-triphosphate granules.
Serum NicAb concentrations elicited by each individual immunogen were not affected by whether the immunogens were administered alone as monovalent vaccines or together as a bivalent vaccine.
The stimulus response curve of the nociceptive RIII reflex was significantly reduced after injection of a combination of ketamine and morphine, but was not modified when placebo or each of the active drugs was administered alone.
Instead, as was the case when the alcohol drink was administered alone, there was a gradual decrease in plasma cortisol levels so that at 180 and 210 min the plasma cortisol concentrations were significantly lower from the basal levels at 0 min (p <.05 Newman-Keuls) for both HR and LR subjects.
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