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Therefore, the resolution of the inflammatory response is highly dependent on the balance between pro- and anti-inflammatory mediators that are additionally regulated by the energetic state of macrophages.
Nevertheless, HIF αs and LDH-5 are additionally regulated by oncogenes and cytokines, which may account for their more diffuse expression than CA9.
IP3Rs and RyRs share structural and functional homology and both are large multi-domain ligand-gated channels that are additionally regulated by Ca2+ itself [ 12].
Pathways regulating gametocytogenesis have been reviewed (Morahan and Garcia-Bustos, 2014); these authors suggest ap2g may regulate pfgdv1, thence pfnek4 and nek2 – genes that are additionally regulated by extracellular factors via cyclic adenosine monophosphate-mediated pathways.
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Although V2C18 and V3C18 share a common promoter, V3C18 is additionally regulated by alternative splicing of FZC18 to produce V2 [7].
The Notch signaling pathway is additionally regulated by increased expression of its inhibitor, Numb that can antagonize the activity of NICD preventing its nuclear translocation [28].
The availability of IGF-1R ligands is additionally regulated by at least six high-affinity IGF-binding proteins (IGFBP1-6) which broadly function to inhibit IGF bioactivity.
DCV transport is additionally regulated by Rab27a.
The system may be additionally regulated through the degradation of MqsA by ClpX/P and Lon proteases [ 35].
In this paper we focus on the DNA level, but it is entirely possible that turnip formation is (additionally) regulated at the transcriptional or even post-translational level.
Since cohesin cleavage is sufficient to trigger chromosome segregation, anaphase onset could be additionally regulated by securin-independent separase inhibition or by making cohesin more resistant to cleavage.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com