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The phrase "are a major issue" is correct and usable in written English.
You can use it to describe a significant problem or concern in various contexts, such as discussions about social, political, or environmental topics.
Example: "Climate change and its effects on biodiversity are a major issue that requires immediate attention from policymakers."
Alternatives: "are a significant concern" or "pose a serious problem."
Exact(52)
Regulatory concerns are a major issue.
Sacks are a major issue for the Bears.
In that dispute, health costs are a major issue.
As in other states, growing public pension costs are a major issue in New York.
Bad loans are a major issue for India's banks, and much of the country remains mired in poverty.
Jobs are a major issue in South Africa, where unemployment is over 25% and income disparities are glaring.
Similar(8)
Environmentalism was a major issue.
Immigration is a major issue.
Online privacy is a major issue today.
Language in France is a major issue.
More suggestions(15)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com