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The phrase "are a main factor" is correct and usable in written English.
It can be used when discussing the importance or influence of certain elements in a particular context or situation.
Example: "Several variables are a main factor in determining the success of the project."
Alternatives: "are a key element" or "play a significant role".
Exact(6)
Sunken oil prices are a main factor in Venezuela's economic collapse, and both events are as bad as any in recent history.
It is also known to all that the slow fluctuations of the target radar cross section (RCS), which result in the radar target fades, are a main factor of degrading the detection and recognition performance of the radar systems [1].
FAO's main interest, we believe, is in current impacts of climate which are a main factor in variability of food production from year to year.
Previous studies have shown that epigenetic modifications, especially those involving small RNAs, are a main factor for the development and growth of plants.
Since the apomicts do not have a fitness advantage with respect to female fecundity, it is likely that superior colonizing abilities, as postulated by Baker's Law (Baker, 1965, 1967), are a main factor for the observed centrifugal distribution.
These results indicate that differences in the contribution of hNTI cells are a main factor associated with the separated clustering of primary tumors and PDX models (Y-axis in Figure 2A and Figure 3B).
Similar(54)
Mr. Carmon, the institute chief, believes that Mr. Barak's rhetoric was a main factor.
Acetaldehyde is a main factor of alcohol-induced asthma.
Using information effectively is going to be a main factor for success in the smart cities.
Concentration of conducting ions is known to be a main factor affecting ionic conductivities of glasses.
Fundamentally, vibration characteristic is a main factor for the stability of structures.
More suggestions(17)
are a fundamental factor
are a substantial factor
are a salient factor
are a core factor
are a main instrument
are a main source
are a main driver
are a main reason
are a main predator
are a main priority
are a main target
are a main information
are a main gauge
are a main feature
are a main cause
are a main reservoir
are a main export
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com