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Patients will hold us all accountable in new and necessary ways The social contract of the randomized controlled trial is imbalanced: patients adhere to arduous protocols, are randomized to placebo, and are blinded to their health status.
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However, all currently used treatment protocols are arduous and time-consuming, and therefore not ideal in therapeutic trials.
Nevertheless, the significance of data from transcriptional studies of islet cells is limited, since the arduous conventional collagenase digestion protocol for procuring pancreatic islets is known to alter gene expression patterns as observed in collagenase-isolated primary adipose cells [ 7– 9].
Furthermore, if the protocol is overly arduous to implement (e.g., requiring substantial time or resource commitments from the clinician or their organisation) clinicians are unlikely to recruit a large number of patients (Hjorth et al, 1996; Ellis et al, 1999; Grunfeld et al, 2002; Weinberg et al, 2004; Tournoux et al, 2006; Fayter et al, 2007).
While stable transformation of gametes or regeneration of whole plants from transformed somatic cells is routinely achieved in model plant species (e.g., by floral dipping in Arabidopsis thaliana), for most non-model species, the lack of suitable protocols and the phenomenon of regeneration recalcitrance make the obtainment of whole-plant transformants an arduous task.
— far more arduous.
The conditions were arduous.
Second, clinical trials are arduous.
"It was pretty arduous," she said.
His start Saturday was considerably more arduous.
"But it is arduous".
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