The complexity and at times redundancy of immune responses to infections often render to arduous and expensive experimental settings when attempting to identify the key components and their temporal contributions during coinfections.
Separation and purification of such highly glycosylated proteins like adhesins by experimental techniques is an arduous task.
However, the construction of one single prediction model seems to be an arduous task that will require comprehensive experimental validations [ 19].
This model was not further developed due to the arduous task of dealing with the experimental procedures, and in our hands, sometimes the tumour expands into the peritoneal area broadening the gap between the model and the human pathology.
That's an arduous way to create, and a rarity, even in experimental theater.
Another challenge is that, even when good initial estimates of parameters values are available, in complex models the verification for identifiability problems (e.g., nonsignificant parameters or parameters correlation derived from experimental design) is a conceptual and numerical arduous task.
2001's Confield abandoned the earmarks of electronic dance music almost entirely for something more experimental; 2013's Exai stretched out across two arduous but ultimately rewarding hours.
The identification of candidate genes within loci associated with human genetic diseases is a difficult task because the identified genomic region typically contains hundreds of genes, making experimental methods employed to identify the specific disease gene arduous and expensive.
Furthermore, ethical standards regarding the use of nonhuman primates in neurobiological research limit the number of primates as experimental animals, and the preparation of acute brain slices from primates is more arduous compared to the preparation of rodent acute brain slices.
The models were created to match the experimental behavior, and their potential use for a buckling analysis needs careful attention because of the arduous task to select the correct equivalent geometrical imperfection (suitable sizes and shapes, as per CEN 2009; Bacco and Borri 1993; Bulenda and Knippers 2001; Schlaich and Schober 1997) in such a simplified model.
