At the same time, a significant stage in Barnes's arduous recovery will be the delivery of his prosthetic legs: not simply objects to him, but vitally important tools for living.
Previously, he looked into the arduous life of a restaurant delivery guy in Take Out, now, with Prince of Broadway, he's casting light on the people who hawk counterfeit fashion to the gullible and the not-so-gullible, and how that market affects their ability to discern truth from fiction.
Development of nontoxic, tumor-targetable, and potent in vivo RNA delivery systems remains an arduous challenge for clinical application of RNAi therapeutics.
After a double mastectomy and arduous treatments, she seems to have beaten the disease, which gave a special resonance to her spunky delivery of lyrics like: "Good times and bum times,/I've seen them all and, my dear,/I'm still here".
It has been quite difficult to identify improved delivery agents for oligonucleotides; one problem has been that many of the assays for antisense activity are arduous.
The conditions were arduous.
Second, clinical trials are arduous.
Economists 12. Arduous 13.
