The last three years have produced two masterpieces of archival profiling in Amy and Cobain: Montage Of Heck.
As discussed earlier, several groups including ourselves have confirmed that archival FFPET profiles mirror those in paired FT samples (Bibikova et al, 2004; Haque et al, 2007), however it is not yet clear how close the resemblance should be to achieve this aim.
We present the largest archival osteosarcoma profiling study to date.
In this study, we set out to assess the feasibility of using archival FFPET profiling for biomarker discovery in tumours where fresh-frozen tissue is in short supply.
The reliable application of archival FFPET profiling to answer biologically relevant questions depends on the extent to which quantitative gene expression relationships are faithfully preserved in FFPET.
Confirmation of these aims would support the notion of using archival FFPET profiling for biomarker discovery in tumours where FT is in short supply.
Lining the downstairs gallery, and more unusual, is an archival section that profiles 28 collectors, beginning with Catharine Lorillard Wolfe and including the Havemeyers, the Lewisohns, the Potter Palmers, Albert C. Barnes and Lillie P. Bliss, as well as Frick and Morgan.
The data show that rRNA integrity is a poor predictor of successful archival FFPE array profiling.
This study aimed to show that useful information can be obtained by Exon-array profiling archival FFPE tumour samples.
The Emerging Technologies for Translational Bioinformatics symposium on gene expression profiling for archival tissues featured presentations of two large-scale FFPE expression profiling studies (each involving over 1,000 samples), overviews of several smaller studies, and representatives from three leading companies in the field (Illumina, Affymetrix, and NuGEN).
