Several earlier studies have shown that the architecture of pathway, in particular, pathway position, shapes the evolution of its genes [ 14, 23, 24].
Accompanying recent advances in determining RNA secondary structure is the growing appreciation for the importance of relatively simple topological constraints, encoded at the secondary structure level, in defining the overall architecture, folding pathways, and dynamic adaptability of RNA.
20 Although informative, such studies on mouse beta cells may not accurately predict human beta cell responses due to differences in the architecture, signaling pathways, and relative proportions of endocrine cells, as well as beta cell proliferative capacity which is robust in young rodents but negligible in humans, especially in individuals >30 years old.
An alternative possibility is that functional redundancy results from a distributed network architecture or pathway compensation, as is seen among the non-paralogous mesodermal genes hlh-1 hnd-1 and unc-120[ 32].
We presented the novel method BioSim to compute and search for functional similarities of genes and proteins based on diverse annotations such as protein interactions, domain architectures, biological pathways and disease associations.
Given the fundamental role of disturbed oxygen homeostasis in human disease and the potential for therapeutic manipulation of the HIF pathway, much interest has focused on understanding the extent and architecture of these pathways.
Chin, C. S., Chubukov, V., Jolly, E. R., DeRisi, J. & Li, H. Dynamics and design principles of a basic regulatory architecture controlling metabolic pathways.
Modelling architecture on neural pathways will most defiantly pave the way for AI and computer systems that function and learn like a brain.
This architecture provides efficient pathways for both lithium and electron transfer, enabling high charge discharge rate performance.
