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The genetic architecture of transcript level variation in the porcine F2 resource population was highly variable and complex.
eQTL studies have been performed on maize, eucalyptus and Arabidopsis [ 21]. eQTL analyses in barley have addressed the global genetic architecture of transcript abundance in [ 22], the phenomenon of limited pleiotropy [ 23] and as an approach to identify the causal or candidate genes underlying partial resistance to fungal diseases [ 24, 25].
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Transcriptome plasticity is conferred not only by altering the concentration levels of transcripts, but also by complex changes in the architecture of transcripts (splice isoforms, editing, transcription start and termination sites).
Similar studies in eucalypts may provide new insights into the genetic architecture of transcript-level variations and post transcriptional gene regulation.
The genetic architecture of transcripts differentially expressed in specific stages of autoimmune diabetes offers novel venues towards our understanding of patterns of inheritance potentially affecting the pathological disease mechanisms.
In addition, we surveyed the architecture of brain transcript regulation and demonstrated preservation of gene co-expression modules in hippocampus and striatum, while also highlighting important differences.
Non-coding genetic variations have been shown to increase disease risk by altering levels of mRNA expression and splicing architecture of mRNA transcripts (30, 31).
Genetic variations may affect levels of expression and splicing architecture of mRNA transcripts (30, 31) thus several studies have tested the relationships between TCF7L2 mRNA expression and genotypes of rs7903146 and rs12255372 in human tissues (28, 32– 32).
This classification will also help researchers gain an insight into the architecture of piRNA precursor transcript as well as their mode of biogenesis [ 15].
These studies have revealed the complexities of transcript architecture, from 5′- and 3′-end heterogeneity to overlapping transcripts and novel transcribed regions.
Additional sequencing and mapping of transcript architecture in other eukaryotes will help establish in the future whether or not P. falciparum truly lies at the extreme of the distribution.
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