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While this approach represents a driving force in drug discovery, there is also a need to perform large-scale screens without disrupting inter-organ communication and tissue architecture, essential components for understanding the complexity of metabolic regulation and the identification of small molecules with appropriate biological activities in vivo.
The enhanceosome model suggests that the DNA-protein complex affects structural architecture essential for regulatory activity and, in accordance, the REP mutations underscore the role that local structural integrity plays in affecting the overall activity of the ZRS regulator.
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But highly ordered cellular architectures essential to the function of complicated organs like the heart are much harder to replicate.
Analysis of collagen architecture is essential to wound healing research.
The unique architecture is essential for the specific physiological functionalities of periodontium.
Multicasting architecture is essential for the delivery of a variety of multimedia applications.
Thus, tropomyosin's pre-shaped semirigid architecture is essential for the assembly of actin filaments.
Precise control over scaffold material, porosity, and internal pore architecture is essential for tissue engineering.
This unique architecture dictates essential aspects of Ca signaling under both normal and diseased conditions.
Normal thymic architecture is essential for the proper development of T-lymphocytes.
The liver also offers tissue engineers an example of a structure in which complex architecture is essential to tissue function.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com