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In order to reveal the basic differences in the network architecture, developmental gene networks are numerically evolved [18] [23] under selection pressure to form a target number of stripes expressed in a specific gene, which we label #1 without loss of generality (Figure S1; see Methods).
Several in vitro C. albicans biofilm model systems are available to elucidate the architecture, developmental stages, cell phenotypes and drug resistance of biofilms (Nett and Andes, 2006).
Because developmental interactions both shape patterns of phenotypic and genetic covariation among characters and evolve in response to selection acting on those characters [ 9, 87], genetic architecture, developmental mechanisms, and population-genetic processes interact in complex ways [ 88].
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Structural equations modelling and rating scale analysis showed that the architecture and developmental patterning of the various processes are basically the same in the two ethic groups.
MLL2 binding is required for changes in chromosome architecture around developmental genes and establishes promoter-enhancer looping interactions in a cell-cycle-dependent manner.
One of the biggest challenges in neuroscience is illuminating the architecture of developmental brain disorders, which include structural malformations of the brain and nerves, intellectual disability, epilepsy, and some psychiatric conditions like autism and potentially schizophrenia.
As the proposed architecture is developmental, meaning that the internal representations are learned from pairs of input and motor signal, and thereby not manipulated internally for a specific task, we argue that the same learning principles and computational architecture can be potentially applicable to other sensory modalities, such as audition and touch.
Chromatin conformation analyses have established the importance of cohesin for the architecture of developmental gene clusters and in vivo studies in mouse and zebrafish demonstrated how cohesin defects lead to gene misregulation and to malformations similar to the related human syndromes.
This contrasting pattern of variation along the ontogeny provides an initial insight to understand the genetic architecture underlying developmental time.
Certainly the combination of the two methods will be of value in defining both static architecture and developmental shifts.
There is therefore considerable potential for increase of the diagnostic yield once understanding of the genetic architecture of developmental disorders has improved.
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