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Moreover, extracellular gaps developed that are indicative of extracellular swelling and tissue architecture breakdown.
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Small deletions disturb desmin architecture leading to breakdown of muscle cells and development of skeletal or cardioskeletal myopathy.
A more homogenous muscle may be caused by loss of muscle architecture due to muscle breakdown, inflammation or fluid retention [16].
According to the letter, McCarthy's work "explores the role of mirrors, spinning, and 'neurotic' architecture — a feeling of psychological breakdown".
The mechanical study indicated better resistance to the breakdown of the architecture of the CNT-containing filled hydrogels.
These engineered tissues will help refine our understanding of the relationship between form and function in the human body, provide new models for the breakdown in tissue architecture that accompanies disease, and serve as building blocks for the field of regenerative medicine.
However, in the erythroid-specific Rb−/− mice, their spleens show an expansion of the red pulp, but not the complete breakdown of splenic architecture observed in the more severely affected Chk1+/− mice.
There was general enlargement (karyomegaly; Figure 4E), suggestive of cellular stress (Chow et al., 2012), and there was breakdown of tissue architecture.
Understanding tissue morphogenesis is important to enhance our understanding of differentiation but also to understand the breakdown of tissue architecture during disease formation.
Altogether, these derangements in heart tissue architecture could participate in the breakdown of sarcomeric proteins and their release in the systemic circulation.
A similar change in tau distribution and phosphorylation has been shown in neurons exposed to oxidative or excitotoxic stress, suggesting a common signaling cascade that culminates in regional tau pathology and eventually in the breakdown of neuronal architecture.
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