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Together, our findings suggest that moderate SMF prevented bone architectural deterioration and strength reduction by inhibiting the reduction of bone formation in T1DM rats, and indicate that SMF might become a promising biophysical countermeasure for T1DM-related osteopenia/osteoporosis.
We found that SMF exposure for 16 weeks inhibited architectural deterioration of trabecular bone and cortical bone and mechanical strength reduction in T1DM rats, as evidenced by the MicroCT and 3-point bending findings.
Osteoporosis is a systemic skeletal disease characterized by low bone density and micro architectural deterioration of bone tissue with a consequent increase in bone fragility [ 1].
Osteoporosis, a systemic skeletal disease characterized by low bone mass and micro architectural deterioration of bone tissue leading to increased fragility [ 1], is a worldwide public health problem.
Osteoporosis is a potentially crippling condition characterized by low Bone Mineral Density (BMD), micro architectural deterioration of bone tissue, and increased risk of fragility fracture.
Osteoporosis is a chronic, multifactorial disorder which is characterized by low bone mass and micro architectural deterioration of bone tissue [ 1].
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Withdrawal of Formulated kaempferol-in OVx rats resulted in the maintenance of bone micro-architecture up to 30 days, whereas micro-architectural deterioration was readily observed in OVx rats treated with unformulated kaempferol-within 15 days of withdrawal.
Osteoporosis is a condition characterized by low bone mass and micro-architectural deterioration leading to non-traumatic fractures of the skeleton.
Together, these results demonstrate an osteoporotic phenotype in Id1−/− mice, characterized by low bone mass and micro-architectural deterioration of bone tissue, with a resultant increase in bone fragility and susceptibility to fracture.
Osteoporosis is characterized by low bone mass and micro-architectural deterioration of bone tissue, which leads to increased bone fragility and risk of fracture.
Osteoporosis is characterised by low bone mass and micro-architectural deterioration of bone tissue, leading to bone fragility and susceptibility to fracture [ 6].
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