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archetypic
adjective
Archetypical
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This is the archetypic tale of the betrayed wife, and it lives on our collective feminine psyche.
The induction of IFNβ could be the archetypic response of this yet to be defined receptor.
As Dictyostelium represents an evolutionary older organism than yeast, Frizzleds may be considered as archetypic receptors, suggesting that they may be compatible with the yeast GPCR- machinery.
Signaling of human Frizzled receptors to the yeast mating pathway is particularly interesting from the evolutionary perspective: Our results suggest that the archetypic GPCR signal transduction machinery of the yeast S. cerevisiae may be related to Frizzled signaling in animals.
Notably, several groups of Thx-like proteins lack one or both cysteines from the archetypic CxxC motif common to most thioredoxin-like molecules.
The three archetypic lineages were predominantly observed in North America and Europe, whereas more divergent genotypes were identified in French Guiana, Mexico, and Brazil [ 2, 5, 6].
These findings confirm that treatment of organoids with archetypic cell death-inducing triggers results in an altered phenotypic appearance and the disintegration of the organoids, likely reflecting excessive cell death.
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