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An appropriate numerical approximation is needed for estimating the underlying functions when dealing with data in the form of discrete sampled points.
Referees have right, there is a huge room for improvements, but a solid based step-by-step, down-to-top approximation is needed for the detailed understanding of the structure formation and stability of TMPs.
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In particular, accurate reduced order approximations are needed for the forward and adjoint dynamical models, as well as for the reduced gradient.
Following this, the second way of modelling the genotypic data in Gianola et al. [ 4], as described above, seems to be an interesting option, because it yields directly the additive effects, if the genotypes are modelled appropriately, and no extra computational step for the linear approximation is needed.
Thus, some approximation is needed in practice.
Therefore, some form of approximation is needed.
An additional approximation is needed to obtain a computable model.
However, an approximation of the Jacobian is needed for the purpose of preconditioning.
In general, such gradient flow cannot be implemented for underactuated control systems, and an approximation of non-admissible velocities is needed for the control design.
A more concerted effort is needed for a better approximation of the country's NPC disease burden.
A field study of the costs and consequences of ELS following multifocal lens implantation is needed for a closer approximation to everyday practice.
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