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Bevacizumab was the first angiogenesis inhibitor that was clinically approved, initially for treatment of colorectal cancer and recently also for breast cancer and lung cancer.
The protocol has been approved initially by the Ethics Committee of the Stuivenberg Hospital in Antwerp followed by the Ethics Committee of each participating center.
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The study was approved and initially funded by the Italian National Centre for Disease Prevention and Control (CCM grant 2010) and by the Italian Ministry of Health (art 12 and 12bis D.lgs 502/92).
Research ethics committees at the Universities of [Cardiff and York] initially approved the study which subsequently gained NHS approval from Berkshire Research Ethics Committee (09/H0505/66).
The classic cases include Sildenafil that was initially approved for angina but repurposed for erectile dysfunction and Canakinumab which was initially tested for Rheumatoid arthritis but was repurposed to treat cryopyrin-associated periodic syndrome (CAPS) [10].
The Federal Aviation Administration initially approved $100 million for the project in 1992, but the approval process dragged on so long that the grant expired.
"Django Unchained" was initially approved.
Nixon initially approved the plan anyway.
In November, Judge Kaplan initially approved the settlement.
The Department of Agriculture initially approved the label, but later said it had made a mistake.
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CEO of Professional Science Editing for Scientists @ prosciediting.com