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Panobinostat (a pan histone deacetylase inhibitor) is approved in combination with bortezomib and dexamethasone for patients with relapsed multiple myeloma who have received two or more previous lines of therapy.
Nab-paclitaxel is a novel therapeutic agent, which was approved in combination with carboplatin in the first-line treatment of advanced non-small cell lung cancer (NSCLC) regardless of histologic subtype in the United States of America by the Food and Drug Administration in 2012 and by the European Commission in 2015.
Doctors and patients had no idea that the drug was so over-stimulating it could only be approved in combination with dangerous addictive tranquilizers.
Bevacizumab is approved in combination with cytotoxic chemotherapy for the treatment of colorectal cancer, non-small cell lung cancer (NSCLC), and breast cancer, as monotherapy for glioblastoma, and in combination with interferon for renal cell carcinoma [9] [11].
DCV has been approved in combination with other anti-HCV agents in Europe and Japan.
19 Sitagliptin has not been approved in combination with other antidiabetic agents.
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On 22 February 2008, the US Food and Drug Administration approved bevacizumab in combination with paclitaxel as first-line chemotherapy in patients with refractory MBC.
The FDA has approved lapatinib in combination with capecitabine for treatment of HER2 positive breast cancer with prior progression on trastuzumab, an anthracycline, and a taxane.
14 16 Several other biologics are approved either in combination with disease-modifying antirheumatic drugs (DMARDs) such as MTX or as monotherapy.
In 2015, FDA approved panobinostat in combination with bortezomib and dexamethasone for the treatment of patients with multiple myeloma [ 38] and belinostat for the treatment of patients with peripheral T-cell lymphoma (PTCL) [ 39].
In December 2008, the United States Food and Drug Administration approved plerixafor in combination with G-CSF for HPSC mobilization in patients with NHL and blood stream undergoing autologous peripheral blood hematopoietic cell transplantation [ 67].
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