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Once the construction of ITER is approved, fusion research will receive a massive boost.
The T20 peptide (Enfuvirtide, Fuzeon), which is homologous to part of the gp41-encoded fusion machinery, is the only clinically approved fusion inhibitor, but over the last decade new generations of T20-like peptides have been developed with improved potency and stability, as well as fusion inhibitors that target alternative gp41 domains.
Enfuvirtide, the only approved fusion inhibitor, inhibits the interaction of gp41 hairpin formation, the process by which two complementary parts of gp41 fold onto one another, shortening the protein and bringing the viral and host cell membranes together.
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Enfuvirtide (ENF) is currently the only FDA approved HIV fusion inhibitor in clinical use.
This was first shown in 2005 when the FDA approved the humanized fusion protein CD152-IgG1 (asatreatments a treatment for RA [ 10].
Interleukin-2-diphtheria toxin fusion protein (IL2-DT; Ontak™) is an FDA-approved fusion protein [ 20, 21].
The only clinically approved inhibitor of virus fusion targets the extended intermediate of the HIV fusion protein, gp41 (Wild et al., 1994; Kilby and Enron, 2003); analogous inhibitors have been designed for paramyxoviruses (Lambert et al., 1996), influenza virus (Lee et al., 2011) and flaviviruses (Schmidt et al., 2010a, 2010b).
An approved peptidic HIV-1 fusion inhibitor, T-20, has shown significant promises in clinical applications.
The five most valuable targets for approved mAbs and Fc fusion proteins are TNF (TNF-α), VEGF, ERBB2 (HER2), MS4A1 (CD20), and PDCD1 (PD-1) (Table 7).
Aflibercept is a soluble decoy receptor fusion protein approved for the treatment of exudative AMD and macular edema associated with RVO.
Governments responsible for the ITER fusion project approved a conservative approach to its construction today in which just a bare-bones reactor will first fire up in 2018.
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