Ixabepilone is currently the only approved epothilone derivative and the most clinically advanced (phases II and III clinical trials), showing efficacy in several patient subgroups and in various stages of breast cancer.
When chairman of the world's oldest bank, Monte dei Paschi di Siena (MPS), he allegedly approved dubious derivatives deals that were hidden from the regulators.
Minocycline is a long-time worldwide approved inexpensive tetracycline derivative that has antibiotic, anti-inflammatory, free radical scavenging and antiapoptotic induction properties [ 30– 30].
Ivermectin is a clinically approved Avermectin B1 derivative (> 90% 22,23-dihydroavermectinB1a and < 10% of 22,23-dihydroavermectinB1b) (Fig 2A, Supplementary Fig S3), used in humans against insect and worm infections, including river blindness caused by Onchocerca volvulus (Thylefors, 2008; Traore et al, 2012).
Here, we review the estrogen agonist/antagonist profile of ospemifene, a novel triphenylethylene derivative recently approved to treat dyspareunia, a symptom of vulvar and vaginal atrophy (VVA) due to menopause, both preclinically and clinically.
Docetaxel, a natural product derivative, is approved to offer some extent of symptomatic and survival benefits for HRPC patients.
Eventually it's likely regulators will approve bitcoin-settled derivatives among major derivatives counterparties.
In the past few decades, the FDA has approved two less-toxic derivatives of cisplatin: carboplatin and oxaliplatin.
When artemisinin derivatives were approved as a first-line treatment in Tanzania in 2006, they were supposed to revolutionise the war on malaria, the biggest killer of children in sub-Saharan Africa.
Despite several antiviral drugs including interferon-α and nucleotide derivatives are approved for clinical treatment for HBV, critical issues remain unresolved, e.g., low-to-moderate efficacy, adverse side effects, and resistant strains.
