Sentence examples for approved compounds from inspiring English sources

Drug repositioning, or putting already approved compounds to new uses, has gained ground in recent years as a cost-saving alternative to traditional drug development.

Molecular docking simulation of variant and wild type (WT) protein was carried out with eight FDA approved compounds that target GSTP1 for treatment of various diseases.

Three FDA approved compounds are used as single agents including the oral retinoid bexarotene and histone deacetylase inhibitors romidepsin and vorinostat.

Our signature comparison and ranking approach yielded benchmarking accuracies of 12 25% for 1439 indications with at least two approved compounds.

We have employed the latter two approaches as well as an in-house drug screen on normal human fibroblasts using a curated publicly available library of FDA approved compounds to establish the frequency with which such drug-gene interactions can be first identified and then validated (modulation of mRNA in cell culture), as well as the degree of overlap between these three approaches.

One alternative to the costly and time-intensive drug discovery process is to repurpose clinically approved compounds for treatment of rare diseases.6 Often, rare monogenic diseases can be viewed as dosage problems caused by supra-physiologic or infra-physiologic levels of functional gene-product, usually altering protein activity.

In a recent screen of a library of FDA-approved compounds, dopamine D2 receptor antagonism was identified as a promising strategy for targeting tau-induced neurotoxicity, as antipsychotics such as azaperone, perphenazine, and zotepine improved the phenotypic features of Tauopathy in worms (Table 1; Figs. 1, 2).

We reasoned therefore that a differential screen using US Food and Drug Administration (FDA -approved compounds may identiFDA -approvedecompoundsvival factors or specific toxins and may be useful for the therapeutidentifyriveitherufacturing of cellselectiveo and posurvivaln vivo.

Recently, a library of U.S. FDA-approved compounds were screened for molecules that block expression of pyoverdine synthetic genes.

Several currently FDA-approved compounds have been shown to preserve ER calcium levels in response to ER stress.

Following pipeline validation, using commonly used drug modulators of autophagy, we screened the Prestwick Chemical Library (http://www.prestwickchemical.com), consisting of 1,120 US Food and Drug Administration (FDA -approved compounds, FDA -approveds of autophagy.