Sentence examples for approved agent from inspiring English sources
We included trials of currently approved medications if the trial included an unapproved test agent that was being used in combination with an approved agent or the approved agent served as an active comparator.
There was a significant increase of 2.6% per year in the number of expedited review and approval programs granted to each newly approved agent (incidence rate ratio 1.026, 95% confidence interval 1.017 to 1.035, P<0.001), and a 2.4% increase in the proportion of drugs associated with at least one such program (odds ratio 1.024, 95% confidence interval 1.006 to 1.043, P=0.009).
Christie remains heavily involved in the sport as a coach to Britain's top sprinter Darren Campbell and as an officially approved agent to some of the country's leading athletes.
In this work, we develop a novel theranostic agent based on Prussian blue nanocubes (PB NCs), a clinically approved agent with strong near-infrared (NIR) absorbance and intrinsic paramagnetic property, for in vivo bimodal imaging-guided photothermal therapy.
There is no randomised study demonstrating the activity of any approved agent after this sequence.
However, there is no widely approved agent available for the treatment of RLS.
All currently approved agents are indicated for abstinence.
The three approved agents have a planar chemical structure that is suitable for binding to β-sheets in Aβ plaques.
Furthermore, there are concerns that on-going phase 3 trials may be contaminated if patients go off study treatment to start 1 of the newly approved agents or take the agent subsequently.
FDA labeling for newly approved agents requires a minimum 5% weight loss within a designated period of time or the patient should be considered a non-responder and the drug discontinued.
Its effect may also be "considerably less than of the approved agents ... Thus it may be prudent for the clinician to recommend a trial of behavior therapy at this point, before moving to these second-line agents".
