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As a result, drug development by major US-based drug companies is in dire straits, with costs up and regulatory approvals down.
But Brian Murphy of the Mortgage Advice Bureau said: "The fact that overall mortgage approvals slipped again - with house purchase approvals down for the second successive month - shows how important it is to encourage more activity in this area".
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Xerox CEO Ursula Burns fell to 28% approval, down from 65% approval last year while Cisco Systems CEO John Chambers fell to 57% approval from 85% a year ago.
This resulted in a slight drop in approval, down from 53.1 to 52.7percentt.
Topiramate is an antiepileptic agent that has FDA pediatric approval down to age 2 for seizure treatment [ 39].
In 2008, about 70% of applications were approved, but approvals were down to 35% in 2012.
The number of mortgage products available has collapsed from 15,000 to 1,500 in just two years, according to Fathom Consulting, with mortgage approvals also down sharply.
For the month, his approval was down 1.3percentto to 47.9percentt, another new low in all-time monthly approval for Obama.
Obama's job approval is down to about 50percentt.
The IRI poll gave him a 21% approval rating, down from 63% a year ago.
Still, Mr. Obama's approval is down from 68percentt in the spring.
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